How to reduce indomethacin-induced gastric mucosal lesions — a new hydrosoluble indomethacin derivative and intra-nasal administration of indomethacin—

Curcumin Prevents Indomethacin-induced Acute Gastric Mucosal Damage in Rats Curcumin Prevents Indomethacin-induced Acute Gastric Mucosal Damage in Rats

Background: Curcumin, a major constituent of tumeric powder, is renowned for its anti-inflammatory effect but the studies of its effects on nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastropathy are still

Effect of intra-uterine administration of indomethacin on ovarian steroids.

Proteolytic enzymes increase the sensitivity of the bronchial system against acetylcholine when inhaled as aerosols. These experiments were performed on 33 dogs in order to localize the area of sensitivity in the bronchial system responsible for bronchoconstriction. Pronase given in a small dosage as proteolytic enzyme aerosol only to the upper part of the airtract sensitises the lower part of ...

Early administration of indomethacin to preterm infants.

Indomethacin (0.2 mg/kg) or saline was given intravenously during the first 24 hours to 50 preterm infants in a double blind controlled trial. Eight of the control group later required treatment with indomethacin for clinical signs of left to right shunt, but only one in the treatment group (p = 0.03). Treatment with indomethacin prolonged bleeding time, raised serum creatinine concentrations, ...

Indomethacin: continuous versus bolus administration.

The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats

Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were ind...